In this episode, we again discuss the research showing that SARS-CoV2's spike protein is sufficient on its own to cause disease. American College of Obstetricians and Gynecologists. New York: SARS-CoV-2 's distinctive "spike" proteins have been known to infect its host by latching on to healthy cells, but scientists have, in a new study, showed . The novel coronavirus spike protein plays additional key role in illness. SciCheck Digest. 1. the vaccine has an imprint (kind of like a foot print but not the foot) of the spike and an enzyme which your immune systems beta cells identify as an antigen it needs to examine. While previously working on a vaccine for MERS, a disease caused by another coronavirus, McLellan and others discovered that by adding two proline molecules to the spike protein, they could lock it into its pre-fusion state, triggering a more effective immune response and preventing cell entry. surfactant in COVID-19 patients. However, it says, based on available data COVID-19 vaccines are thought not to be a risk.. According to the Centers for Disease Control and Prevention, the most intensive safety monitoring in U.S. history has found that most of the reported side effects after COVID-19 vaccination are minor, such as pain at the injection site or fever. Having said that, a more complete answer would depend on the age and health status of the vaccinated individual. Much like any other vaccination in a breast feeding person, even if the spike protein makes it into the milk, the protein would be degraded by the stomach acid. This is the issue, why create spikes inside cellular machinery? NSP1 halts host protein production. Until he approached it and looking down saw down into the earth and was alarmed. Pharmacokinetics is the study of how a drug moves through the body, including how quickly drugs are absorbed, metabolized, and excreted. The new findings could help explain . It is a beautiful forest with trees so tall and wide. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827936/#:~:text=SARS%2DCoV%2D2%20uses%20its%20viral%20membrane%20fusion%20protein%2C,(ARDS)%20%5B5%5D. COVID-19 vaccine for children. Statement, Canadian Paediatric Society. SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy bioRxiv. The document was part of the submission data applied by Pfizer to PMDA (Japans version of FDA) for its review, and it is publicly available online, Ghazvini said. BNT162b2 vaccination induces SARS-CoV-2 specific antibody secretion into human milk with minimal transfer of vaccine mRNA, Viral Posts Misuse VAERS Data to Make False Claims About COVID-19 Vaccines. Email sent to FactCheck.org. New research: Besides initiating infection, coronavirus spike protein has key role in illness The paper also finds that Covid-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system (comprising the blood vessels) on a cellular level. Dmitry Lyumkis A passion for problem solving. "Novel coronavirus' spike protein plays additional key role in illness: Researchers show how the protein damages cells, confirming COVID-19 as a primarily vascular disease.". Researchers detected levels of SARS-CoV-2 protein as early as one day after the first injection in 11 of the 13 participants. This research goes against all cellular biology. This article is a reprint of what I assume is the original source here: https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/. 14 June 2021. The commonality between them is that they all have vascular underpinnings.. 21 May 2929. on SARS-CoV-2 antibodies in breast milk following vaccination, told us there is no evidence to support Bridles claims. It must first be understood by all. Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together. SARS-CoV-2 virus RNA. what is the half -life or the time scale the mRNA and the proteins will be floating around until mRNA is degraded and the spike proteins are met by the immune system? To fuse its viral membrane with the host cell membrane it substantially changes its shape from an unstable pre-fusion state to a stable post-fusion state. Because the vaccine produced spike proteins are locked into this state, they cannot properly bind to the ACE2 receptors in other, healthy cells. Even if its turns out to be true that mRna spike proteins can harm your cells. 15 June 2021. The CDC and FDA vaccine safety monitoring systems, which were expanded for the COVID-19 vaccines and also include a new smartphone-based reporting tool called v-safe, have subsequently identified only a few, very rare adverse events. Since the pandemic started, his lab has been trying to develop vaccines against coronaviruses, for which he. The Institute is an independent nonprofit organization and architectural . An explosive new study by researchers at the prestigious Salk Institute casts doubt on the current crop of gene-based vaccines that may pose a grave risk to public health. Some one in the scientific community must comment on the joint sites of cooperationof the research and the varied nationality of the scientists working on the project! The foundation has. Theunpublished study found antibodies in the breast milk from all of the workers andminimal amounts of vaccine mRNA.. They travel extensively through the lymph system and a large number end up in the spleen. if genetic alterations in pathways that control surfactant This conclusion suggests that vaccination-generated antibody and/or exogenous antibody against S protein not only protects the host from SARS-CoV-2 infectivity but also inhibits S protein-imposed endothelial injury. press@salk.edu. 01 Professor Susan Kaech, who studies how we develop immunity to severe viral infections, such as It is now known that many of the toxid effects of being infected by SARS COV 2 stem directly from the spike protein ie the spike protein itself is a pathogen. Can not happen as this paper suggests. LA JOLLA, CA Scientists at Scripps Research have obtained high-resolution, atomic-scale details of the structure of a SARS-CoV-2 "spike" protein from an experimental COVID-19 vaccinedetails that are consistent with the robust neutralizing antibody responses the vaccine elicited in preclinical and phase 1 clinical studies. 21 May 2021. Vol. 10 June 2021. Weiss, Susan. associated with more severe disease. Professors Clodagh OShea, Anyone can submit a report of an event to VAERS, even if its not clear that a vaccine caused the problem, and all of the notifications are accepted without determining if the event was caused by a vaccine. Every cure has a starting point. Based on this outline, we have reviewed the structure . And so theres no risk of transmission through the breast milk. The process prepares the body against future infection. And I understand some clots as well, including with the Pfizer vaccine.I am asking this also because I want to get vaccinated but just like the previous comment with the autoimmune condition, I have had an autoimmune condition, the hives on and off for the past 15years (I am not that young anymore though), cause unknown although stress and some chemicals make them worse. The spike proteins from the virus and the ones generated by the vaccines are essentially the same, McLellan, the spike protein researcher at the University of Texas at Austin, told us, noting that they have the same function, structure and way of processing. BNT162b2 vaccination induces SARS-CoV-2 specific antibody secretion into human milk with minimal transfer of vaccine mRNA. medRxiv. For more, see How safe are the vaccines?. The mRNA vaccines builds the protein within the safe environment of the host cell structure from the inside outspikes are not created outside this environment. Furthermore, the study concludes that vaccines not only protect people from SARS-CoV-2 infection, but also from damage to the endothelium, a thin membrane that lines the inside of the heart and blood vessels. I agree that if the mRNA vaccines themselves stimulate the human bodys cells to produce spike proteins, shouldnt there be some concern that by this process the mRNA vaccines could ultimately cause the same vascular damage? Wow. Accessed 29 June 2021. For proof, see for instance https://www.aljazeera.com/news/2021/5/3/india-covid-cases-near-20-million-uk-to-send-more-aid-live-news. Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.. Accessed 29 June 2021. These vaccines have been found to be effective and safe in clinical trials with tens of thousands of participants, and in real world conditions with over 325 million doses administered. The one Dr. Malone particularly pushed is from Salk Institute, where researchers injected SARS-CoV-2 spike proteins into hamsters, which injured the lungs and blood vessels due to angiotensin . But does that hold true for the rest of us? Centers for Disease Control and Prevention. The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. It is because of these features that this part of the spike protein should never have been included in a vaccine. Kelly, Jeannie. Pharmacokinetics is the, Virus Spike Protein vs. Vaccine-Generated Spike Protein, Thats because the SARS-CoV-2 spike protein is a, . Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. More information: Isabelle Montgomerie et al, Incorporation of SARS-CoV-2 spike NTD to RBD Protein Vaccine Improves Immunity Against Viral Variants, iScience (2023). Research from the lab of Professor Satchin Panda has found that the majority of our genes follow a day/night rhythm in many tissue types and brain regions. You may unsubscribe via the link found at the bottom of every email. But recent studies in animals and cultured cells have found . . Science in 5. Kaech . The CDC and FDA vaccine safety monitoring systems, which were expanded for the COVID-19 vaccines and also include a new smartphone-based reporting tool called. This treatment will prevent the virus This is an a synthetic form of Human Vasoactive Intestinal Polypeptide (VIP). synthetic virology and chemical biology platforms, to create Episode 41. Spikes proteins can not be floating around after being made and transit to other AC2 receptors elsewhere in the body. The spike protein vaccine with the 2P mutation . Founder and currently Executive Editor of Science-Based Medicine Steven Novella, MD is an academic clinical neurologist at the Yale University School of Medicine. 02 Gerald Pao, a staff scientist in the Hunter lab, will work Walt, a pathology professor, added there is no evidence that the spike protein is a pathogenic protein that causes damage in several tissues. inhibitory factor) plays a role in pancreatic cancer. The, , called 2P, as in two proline molecules, is, No Evidence Vaccine-Generated Spike Protein Is Harmful, prepared in response to the attention brought by the interview, Bridle says the Canadian government should be called upon to immediately halt the mass vaccination program of children and adolescents. He says there is no immediate threat of severe COVID-19 in the majority of Canadian children and adolescents, and that more safety and efficacy data is needed for the use of experimental vaccines., the use of the Pfizer/BioNTech COVID-19 vaccine in children 12 to 15, following authorization of the vaccine in youth 16 years old and older in December. Accessed 29 June 2021. . The vaccines were supposed to be staying in the arm where the recipient was jabbed but this is now known to be false. Vaccines that trigger spike protein production only affect a very limited number of cells, as the genetic material that these vaccines contain does not auto-replicate in the body. Why did he or she do it ? Retweet. Cellular biology 101. That video from a Canadian talk radio show purports to reveal that spike proteins in the vaccines break down cells, allowing the proteins bind and infect the vaccinated. 6. of an individuals COVID-19 infection and limiting the virus We discuss the paper, the authors' clarification. Alan Saghatelian and Joseph Noel are exploiting the atomic National Institute of Allergy and Infectious Diseases. That if one drink from it ! A study out of Israel implies that prepping the immune system to expect the original COVID-19 may paradoxically put it at a disadvantage when exposed to the South African variant. Dont the mRNA vaccines produce spike proteins? 5 May 2021. William, its been known since early in the pandemic that maybe 50% of people are not susceptible (that is, who dont have visible symptoms). The new technology treatments give mRNA to teach your own cells to make the spike proteins. overreaction seen in some COVID-19 patients. helps the virus in promoting the production of its own viral 10 June 2021. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2, Yuyang Lei, Jiao Zhang, Cara R Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X-J Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, and John Y-J Shyy, Office of Communications Credit: Salk Institute. Tel: (858) 453-4100 Had to look down and seen it ! . Canadian Covid Care Alliance. COVID-19 patients to determine if a drop in surfactants is compare surfactant levels with the health outcomes of Scientists have known for a while that SARS-CoV-2 's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. Most of them have appeared in countries with multiracial populations, though. COVID-19 vaccines do not contain a live virus, so there isn't a biological path for a vaccinated person to "shed" the SARS-CoV-2 spike protein to those around them. Newswise LA JOLLA-- (April 30, 2021) Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. Vol. University of Guelph. They spent 12 years solving a puzzle. However, it says, based on available data COVID-19 vaccines are thought not to be a risk.. In the radio interview with Pierson, Bridle says he and other international collaborators obtained the document through a request for information to a Japanese regulatory agency, claiming that it shows for the first time ever where the mRNA vaccines go after vaccination.. Okay they are in the cell so what? Vol. To fuse its viral membrane with the host cell membrane it substantially changes its shape from an unstable pre-fusion state to a stable post-fusion state. protein NSP2 affects host cells during the Experts say the spike protein created by the human body after mRNA vaccination is different than the SARS-CoV-2 spike protein. Episode 41. WHAT WE FOUND "The bottom line is the vaccine spike. If provided, your email will not be published or shared. In addition, the Food and Drug Administration inspects vaccine production facilities and reviews manufacturing protocols to make sure vaccine doses are of high-quality and free of contaminants. (Salk Institute) Usually, a person's immune system turns on when it's needed, slays an infection, then turns off. When either Sars-CoV-2 or HIV infects a person both viruses only cause an innocuous flu-like infection but like HIV, the Sars-CoV-2 spike protein can linger in the body attacking the T cells of the immune system. (a pretty tall order) There is not enough of the viral matter in the vaccine to do significant harm without replication, which it cannot do. This helps to stop the cytokine storm in the beginning and repairs your lungs (if not to damaged). It involves production of antibodies capable of covering areas across the entire spike. Bridle, Bryam. Surfactant is a substance The findings help explain COVID-19s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies. So by vaccinating people we are inadvertently inoculating them with a toxin.. May 3 2021 Scientists have known for a while. The spike protein is not pathogenic. Anyone can submit a report to VAERS for any health problem that occurs after an immunization. Instead, each carries molecular instructions, called messenger RNA (mRNA), that tell our bodies how to fight off the virus. FACT: The COVID-19 vaccine will not affect fertility. Because COVID-19 affects so many bodily systems, Panda is studying gene activity in COVID patients to see how day-to-day changes in this activity and the clinical symptoms of COVID predict treatment outcomes. And he can transfuse wiping away this virus. The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions. So the vaccines should be perfectly safe, even in light of this new information. 21 May 2929. This is not the first paper to show this, Magro (2020) showed this definitively.A synethetic mRNA gene is a great way to make spike proteins and cause damage because lipid nano-particles can travel into the brain whereas the virus does not. Her lab, in collaboration with The Scripps Then: lab leak hypothesis continues to gain ground. breastfeeding after vaccinations may provide babies with protection. Retweeted. That could explain why some people have strokes, and why some people have issues in other parts of the body. Science. Fact check: COVID-19 vaccines dont produce dangerous toxins. USA TODAY. World Health Organization. Severe adverse reactions to the vaccines have been rare. The research findings will impact predictions of COVID patients disease course when they check in to the hospital and finding the right treatment to accelerate recovery. No.I also got a history of rare autoimmune disease involving the blood vessels.The question is, do these spike proteins stay in the cells long enough to produce any damage ? Segments of the interview were widely spread in social media platforms in English and Spanish. via rigorous testing in clinical trials prior to authorization or approval, followed by continued safety monitoring once the vaccine is rolled out to the public to detect potential rare side effects. Some such claims are. Office of Communications. The Pfizer and Moderna vaccines work by introducing mRNA (messenger RNA) into your muscle cells. BUT: Then the immune system will destroy that cell (also some brain cells which will not regenerate). Rajasree Kalagiri Bound to phosphohistidine. 03 In collaboration with UC San Diego, USC and Sanford Updated 21 June 2021. The highest concentration of BNT162b2 mRNA in the tested samples was 2 ng/mL a hypothetical 0.667% of the original vaccine dose being transferred in 100 mL of human milk, the study says. Pfizers vaccine pharmacokinetics overview. Furthermore if vaccine induced spike were pathogenic wouldnt we see a lot of illness following vaccination?, Finally, Bridle says there is evidence that the mRNA vaccines get transferred through breast milk, citing apreprint from Singapore that tested milk samples from 10 lactating health care workers after they were immunized with the Pfizer/BioNTech vaccine. Funke, Daniel. Can I reverse it? The spike protein is unique to SARS-CoV-2 - it doesn't look like other proteins your body makes. in May, collected plasma from 13 health care workers at the Brigham and Womens Hospital in Boston who had received two doses of mRNA vaccine. They showed that the spike protein damaged the cells by binding ACE2. A post widely shared on social media claims a viral immunologist said COVID-19 vaccines' spike protein means people are being inoculated "with a toxin." Experts say there is no evidence that the . combine CRISPR with an imaging technology, so that it will only . Who committed such evil ? McLellan, Jason. The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. 6. It will take a virus to kill a virus. Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab. transformative vaccines and gene therapies. Now, when the cell gets destroyed, all spike proteins which were produced shortly and did not become destroyed yet will float through your tissue and if you are unlucky, enter a blood vessel. In the case of the COVID-19 vaccines, randomized controlled trials involving tens of thousands of people, which were reviewed by multiple groups of experts, revealed no serious safety issues and showed that the benefits outweigh the risks. 01 Professor Juan Carlos Izpisua Belmonte is collaborating with See: https://www.regulations.gov/document/FDA-2020-N-1898-0246. Now, a . MAN WAS CREATED BY GREAT INTELLIGENCE. In addition to Salks ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. Taken together, it looks as if Operation Warp Speed delivered a questionable vaccine but to recoup their losses Big Pharma still needs to put the jab into peoples arms even though much more is unknown than known! The spike protein, particularly the RBD, is therefore the main antigenic target for vaccine formulation. There is no risk at all because all the vaccines that are being used presently, none of them have the live virus in it.
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